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	Steroid metabolome in human physiology and pathophysiology. Hána, Václav ; Hill, Martin (advisor) ; Meloun, Milan (referee) ; Čáp, Jan (referee) Many studies have shown steroid hormone changes in adrenal incidentalomas with subclinical hypercortisolism and various forms of Cushing's syndrome. The aim of our work was to measure, using novel steroid GC-MS/MS measurement procedure, complex picture of many steroids in these patients. With the knowledge of these changes we could better explain causal pathophysiologic changes. In the study on patients with adrenal incidentalomas we described complex steroid changes in patients with subclinical hypercortisolism. Previous studies showed decrease of DHEAS in subclinical hypercortisolism. We confirmed this finding and described a decrease in other androgens and their metabolites. We also evaluated their sensitivity and specificity when compared to routinely used parameters for diagnosis of subclinical hypercortisolism. Furthermore, we looked at the alterations in all measured steroids and their changes in the 1 mg dexamethasone suppression test. In another study, we analyzed steroid changes in various forms of Cushing's syndrome. We confirmed the decrease of adrenal androgens in the ACTH independent forms and mild increase in the ACTH dependent forms. We also described elevations of mineralocorticoid precursors in central and ectopic forms of ACTH secretion. In the distinction of ectopic and central... Detailed record
	Influence of long-term corticotherapy on human organism and possibilities of infulencing its effect by physical therapy Pilátová, Markéta ; Procházka, Michal (advisor) ; Radvanský, Jiří (referee) Detailed record
	Influence of long-term corticotherapy on human organism and possibilities of infulencing its effect by physical therapy Pilátová, Markéta ; Procházka, Michal (advisor) ; Radvanský, Jiří (referee) Detailed record

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